My engine should actually be close to 19:1 as I used the Mahle 18:1 marine pistons, and the block took a 0.010" to get things straight & square.
For now, I'm just running my stock GM-4, and my Kennedy chip/stock PCM/vac pump/solenoid will maintain up to 15 psi, or a bit more. I haven't put an IC on yet, & I tend toward the conservative side, when considering how hard to push an engine design w/ less than stellar track record.
You only really know where the limit of an engine is, when that limit's been found by a failure. I mostly do this mechanical work/hobby because I enjoy it - parts breakage & the associated expense can really take a good deal of enjoyment out of the experience.
While I spent $ perhaps beyond practical rewards, my goal was to build an engine that should comfortably outlast the truck - unless I get too enthusiastic & break it by pushing too hard. I just don't see the 6.5 as a logical foundation to go for big power with. I'm all for those that want to push the 6.5 envelope, but have little interest in doing so w/ my own $ & time.
Absolutely... I am with you on not wanting to push the engine to failure. I feel my engine now at 13psi with the IC and stock compression is pretty decent for what it is. I'd like to try 20psi with 18:1 but only as long as durability and longevity isn't compromised. I can't imagine trying to run 30+ psi on a 6.5. But just to ask does your engine run substantially different with the low compression and 15psi than before the build?