Yeah, thats where you have to put it in hummers and vans with the center mount turbo.
What I do is start the engine and let it idle while drilling the hole. That way the exhaust blows out the shavings instead of dumping them in the turbo. Then when (if) you tap threads in, use a lot of cutting oil and the fine shavings will stick to the tap. Remember to do 1/2 turn in and 1/4 turn back to not break tap. Every 2 full rotations I like to remove, clean, reoil tap.
As for the "exact temp" things should be, it will change based on many variables. Just learn where "normal" is when not loading the engin heavy. You will start seeing a correlation between an egt range and coolant temps when pulling hills or towing. Then you know where to back out of it.