Just ignition won’t make any noticeable changes for the good.
The reason people upgrade ignition- spark plugs, coil energy, etc. is because they are putting in more fuel than normal and they need to ignite that excess of fuel.
You can look up better spark plugs, better distributor, better coil, better wires.
You can spend well over a grand doing all that and if the truck is stock, it will doa better job than stock ignition parts- but them being new vs brand new stock parts- you might see a 2% improvement.
If your ignition system is toasty/ worn out and has to be replaced right now anyways and you plan to redo the engine for more power as you go- then yes now is the time to upgrade it. MAYBE. There is a level that too much spark will do damage if you are not pushing enough fuel and depending on system enough air like needing super charger or turbo charger.
You have to decide what level you are building to before you start.
Showing the extreme is best example I can give. If you were gonna use nitro methane fuel, you have to have a magneto distributor putting out 400,000 volts. Less ignition wont let the fuel burn in time. But run that much voltage means no spark plug lasts 3 miles. Run that much voltage on regular gasoline will burn holes through your pistons and burn out the valves in 1/2 mile drive.
Obviously no 4.3 can withstand nitro methane, so we know you aren’t doing that.
But knowing what you are building is critical.
I would not upgrade just minor parts of the ignition system. Do it all at once because things like a stronger coil will exceed crappy wire insulation capacities.
Understand once you upgrade to bigger coil for instance- you can not go back to stock without replacing it all. So don’t do this if you are broke and might not afford the high dollar plug wires later. Performance is for go fast now and replace more frequently. Don’t think stock lasted 100,000 miles so high performance will make it same time- it will not. High performance coil, wires, plugs last about half the time as stock.