There's nothing wrong with the 4.3l vortec's. Great engines, just suffer the same flaws as other late 90's GM vortec's(spider injectors, intake gaskets, and distributor), but they're all easily fixable.
Back a few years ago my dad gave me a 2002 Chevy S-10, Extended Cab, 4x4, with the 4.3 liter V-6. He had drove it for years put lots of miles on it. When he gave it to me it had around 133,000 miles on it. I am sure a lot of those miles were kind of like MS. Daisy miles, I don't think he blew the soot out of it that often. He told me , son you will have to take it easy on it, its got a lot of miles on it and I had the transmission rebuilt a few years ago. I thought well heck, I am not going to get run over on the road, I will maintain the speed limit and if it blows up, we will deal with it later. The truck still has pretty good pep about it, it will spin a tire pretty easy if you get on it a little heavy.
Since he gave it to me, i had to have another transfer case and other 4x4 stuff replaced. ok, I can spend a few bucks here and there. I noticed that the fuel mileage was pretty disappointing around 13.5 to 14 MPG. My dad had said oh it gets great fuel mileage?
About a month or so ago i was in the big city, hitting the interstate and the truck just shut down, I maneuvered thru 2 lanes of traffic to get to the right hand shoulder, stupid bastards, didn't cut me much slack it was a dog fight . For the first time ever I called AAA, since I have been a member for many years. I didn't care who showed up I just wanted away from those dam idiots that were blasting past me at 60 MPH, acting like I was just a bug on the side of the road. Well I know all the dangers of being stranded beside of the road, but that was the FIRST TIME in my lifetime. I had my 9MM pistols, and my 12 GA. Shotgun behind the seat, I was not worried about undesirables wanting to attack me, I was more worried about getting run over. Trust me i have seen too many times how people have been run over and killed beside of the road, it does not matter if your in a toyota camry or a tractor and trailer some dip wad will come along and wipe you out.
AAA towing service showed up within 10 minutes, i thought wow. The row back driver said he was in the area and got the call from AAA. it costed me 80 bucks for the tow, since it was over 20 miles away to my house, I didn't care about going to some city slicker mechanic place with in 2 or 3 miles, which would have been free for the tow.
Needless to say I got my local repair guys to work on my S-10. They ended up putting a new distributor in it and I swear the fuel mileage has went up 2 to 3 MPG. Truck has about 145,000 or so on it now, it leaks oil for sure, but its still running, i add some oil to it now and then, drive it till it dies.